Publications

Jäger S, Tittelmeier J, Dang TL, Bellande T, Redeker V, Buell AK, Hennig J, Melki R*, Nussbaum-Krammer C,* Bukau B*, Wentink AS*. Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation. EMBO J. 2025 Oct 6. doi: 10.1038/s44318-025-00573-3. Epub ahead of print. PMID: 41053261.

Sandhof CA, Martin N, Tittelmeier J, Schlueter A, Pezzali M, Schoendorf DC, Lange T, Reinhardt P, Ried JS, Liang S, Uzunoglu G, Gasparini L, Jahn TR, Ehrnhoefer DE, Nussbaum-Krammer C*. A novel C. elegans model for MAPT/Tau spreading reveals genes critical for endolysosomal integrity and seeded MAPT/Tau aggregation. Autophagy. 2025 Sep 4:1-19. doi: 10.1080/15548627.2025.2551676. Epub ahead of print. PMID: 40851193.

https://doi.org/10.7554/eLife.106865.1Tittelmeier J, Sandhof CA, Martin N, El-Kabarity D, Ngonza-Nito S-B, Melki R, Nussbaum-Krammer C*. Sphingolipid imbalance aggravates tau pathology by endomembrane rigidification and rupture. eLife. 2025. 14:RP106865. https://doi.org/10.7554/eLife.106865.1

Tittelmeier J, Nussbaum-Krammer C*. Broken Balance: Emerging Cross-Talk Between Proteostasis and Lipostasis in Neurodegenerative Diseases. Cells. 2025 Jun 4;14(11):845. doi: 10.3390/cells14110845.

Tittelmeier J, Kaub L, Milz S, Kugelmann D, Hof PR, Schmitz C, Nussbaum-Krammer C*. Insufficient low-level near-infrared light penetration challenges the efficacy of transcranial photobiomodulation. Brain Stimulation. 2025. DOI: 10.1016/j.brs.2025.07.001.

Desai J, Huyghe E, Maffulli GD, Nussbaum-Krammer C, Tittelmeier J, Schmitz C. Extracorporeal shock wave therapy for erectile dysfunction: rethinking study design, implementation, and analysis. Br Med Bull. 2025 Apr 4;154(1):ldaf004. doi: 10.1093/bmb/ldaf004.

Sandhof CA, Martin N, Tittelmeier J, Schlueter A, Pezzali M, Schoendorf DC, Lange T, Reinhardt P, Ried JS, Liang S, Uzunoglu G, Gasparini L, Jahn TR, Ehrnhoefer D, Nussbaum-Krammer C*. A novel C. elegans model for Tau spreading reveals genes critical for endolysosomal integrity and seeded Tau aggregation. BioRxiv. 2024. https://www.biorxiv.org/content/10.1101/2024.11.13.619586v1

Jäger S, Tittelmeier T, Dang TL, Bellande T, Redeker V, Buell AK, Melki R*, Nussbaum-Krammer C*, Bukau B*, Wentink AS*. Structural polymorphism of α-synuclein fibrils alters pathway of Hsc70 mediated disaggregation. BioRxiv. 2024. https://www.biorxiv.org/content/10.1101/2024.12.02.626355v3.full

Voisine C, Nussbaum-Krammer C. Using C. elegans to Monitor Proteostasis Imbalances. J Vis Exp. 2022 Aug 24;(186). doi: 10.3791/64643. PMID: 37590517.

Tittelmeier J, Druffel-Augustin S., Alik A., Melki R., Nussbaum-Krammer C*. Dissecting aggregation and seeding dynamics of α-Syn polymorphs using the phasor approach to FLIM. Commun Biol. 2022. 5, 1345. https://doi.org/10.1038/s42003-022-04289-6.

Hoppe SO, Uzunoğlu G, Nussbaum-Krammer C. α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies? Biomolecules. 2021; 11(7):931. https://doi.org/10.3390/biom11070931.

Klionsky DJ, […], Nussbaum-Krammer C, […]. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi:10.1080/15548627.2020.1797280.

Tittelmeier J, Nachman E, Nussbaum-Krammer C. Molecular chaperones: a double-edged sword in neurodegenerative diseases. Front. Aging Neurosci. 2020; https://doi.org/10.3389/fnagi.2020.581374.

Sandhof CA, Hoppe SO, Tittelmeier J, Nussbaum-Krammer C. C. elegans models to study the propagation of prions and prion-like proteins. Biomolecules 2020; 10(8);  https://doi.org/10.3390/biom10081188.

Léger P, Nachman E, Richter K, Tamietti C, Koch J, Burk R, Kummer S, Xin Q, Stanifer M, Bouloy M, Boulant S, Kräusslich H-G, Montagutelli X, Flamand M, Nussbaum-Krammer C, Lozach P-Y. NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice. Nat Commun 2020 Jul 01:11,3281. https://doi.org/10.1038/s41467-020-17101-y.

Nachman E, Wentink AS, Madiona K, Bousset L, Katsinelos T, Allinson K, Kampinga H, McEwan WA, Jahn TR, Melki R, Mogk A, Bukau B, and Nussbaum-Krammer C. Disassembly of Tau Fibrils by the Human Hsp70 Disaggregation Machinery Generates Small Seeding-Competent Species. J Biol Chem. 2020 Jul 10;295(28):9676-9690. doi: 10.1074/jbc.RA120.013478. Epub 2020 May 28.

Tittelmeier J, Sandhof CA, Ries HM, Druffel-Augustin S, Klemmer A, Mogk A, Bukau B, Nussbaum-Krammer C. The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α-synuclein species. EMBO J. 2020 Jul 1;39(13):e103954. doi: 10.15252/embj.2019103954. Epub 2020 May 25.

Mattos de EP, Wentink A, Nussbaum-Krammer C, Hansen C,  Bergink S, Melki R, and Kampinga HH. Protein quality control pathways at the crossroad of synucleinopathies. J. Parkinsons Dis. 2020;10(2):369-382. doi: 10.3233/JPD-191790.

Sandhof CA, Hoppe SO, Druffel-Augustin S, Gallrein C, Kirstein J, Voisine C, Nussbaum-Krammer C. Reducing Insulin/IGF1 Signaling Protects Against Non-Cell Autonomous Vesicle Rupture Caused by SNCA Spreading. Autophagy 2020 May;16(5):878-899. doi:10.1080/15548627.2019.1643657. Epub 2019 Jul 29.

Wentink A, Nussbaum-Krammer C, Bukau B. Modulation of Amyloid States by Molecular Chaperones. Book chapter in “Protein Homeostasis”, 2nd Edition. Cold Spring Harbor Perspectives in Biology. 2019 Jul (ISBN: 978-1-621822-96-7).

Chandramowlishwaran P, Sun M, Casey KL, Romanyuk AV, Grizel AV, Sopova JV, Rubel AA, Nussbaum-Krammer C, Vorberg IM, Chernoff YO. Mammalian amyloidogenic proteins promote prion nucleation in yeast. J Biol Chem. 2018 Mar 2;293(9):3436-3450.

Ries HM, Nussbaum-Krammer C. Shape matters: the compley relationship between aggregation and toxicity in protein-misfolding diseases. Essays Biochem. 2016 Oct 15;60(2):181-190.

Agircan FG, Hata S, Nussbaum-Krammer C, Atorino E, Schiebel E. Proximity mapping of human separase by the BioID approach. Biochem Biophys Res Commun. 2016 Sep 16;478(2):656-62.

Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI. Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J. 2015 Sep 14; 34(18): 2334–2349.  

Gao X, Carroni M, Nussbaum-Krammer C, Mogk A, Nillegoda NB, Szlachcic A, Guilbride DL, Saibil HR, Mayer MP, Bukau B. Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils. Mol Cell. 2015 Sep 3;59(5):781-93.

Nussbaum-Krammer CI, Neto MF, Brielmann RM, Pedersen JS, MorimotoRI. Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans. J Vis Exp. 2015; (95): 52321

Nussbaum-Krammer CI, Morimoto RI. Caenorhabditis elegans as a model system for studying non-cell autonomous mechanisms in protein-misfolding diseases. Dis Model Mech. 2014 Jan 7(1): 31-39.

Hofmann JP, Denner P, Nussbaum-Krammer C, Kuhn PH, Suhre MH, Scheibel T, Lichtenthaler SF, Schätzl HM, Bano D, Vorberg IM. Cell-to-cell propagation of infectious cytosolic protein aggregates. Proc Natl Acad Sci U S A. 2013 Apr 9; 110(15): 5951–5956.

Nussbaum-Krammer CI, Park K-W, Li L, Melki R, Morimoto RI. Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans. PLoS Genet. 2013 Mar;9(3):e1003351.

Krammer C, Kryndushkin D, Suhre MH, Kremmer E, Hofmann A, Pfeifer A, Scheibel T, Wickner R, Schätzl HM, Vorberg I. The yeast Sup35NM domain propagates as a prion in mammalian cells. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):462-7.

Krammer C, Schätzl HM, Vorberg I. Prion-like propagation of cytosolic protein aggregates: insights from cell culture models. Prion. 2009 Oct;3(4):206-12.